Use of inspite of

 In spite of and despite uses as a preposition to denote 

Any worked have been done though there have sufficient level of restrictions to do it. 

In spite of my illness, I went to school.

Despite my illness,  I went to school. 

Regardless of uses when something is happen without consideration of any drawback of it. 

He got the job, regardless of his poor education .

In spite of/despite are same meanings. Both stands for doing something where something exist to restrict to do this.